Micro robot developed by Hong Kong university team can kill 99% of dangerous bacteria in medical implants, team says
- Chinese University of Hong Kong team says magnetically powered mini robot acts like brush to scour away biofilm build-up inside devices such as stents and catheters
- Professor Tony Chan says device could prevent ‘serious infections’, improve treatment and boost recovery of patients
Hong Kong researchers have developed a micro robot powered by magnets that can remove build-ups of dangerous bacteria inside medical devices and minimise the risk of infections linked to implants in patients.
“Our device can help prevent serious infections and aid patients’ recovery and treatment,” Tony Chan Kai-fung, a research assistant professor at the university’s Chow Yuk Ho Technology Centre for Innovative Medicine, said.
Biofilm, made up of disease-causing bacteria and other microorganisms, is a slimy substance that can grow in medical implants inside patients.
It can also be found in other settings, such as dehumidifier water tanks.
Biofilm growing inside a patient’s body is hard to tackle and can be the cause of recurring infections.
“Currently, surgery is performed to clear the biofilm or replace an implant,” Chan explained. “But those implants are usually deep inside a patient’s body and surgery to replace implants can bring harm to the patient.”
Another treatment uses high dosages of antibiotics to kill the bacteria, but Chan said that could aid the development of drug-resistant superbugs.
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“We hoped to develop a method to treat biofilm infections without using antibiotics,” Chan said.
The wormlike micro robot, made up of magnetic materials, can swirl at speed, navigate through a tiny tube with the help of an external magnetic field power source and break up biofilm slime.
“The wobbling movement of the micro robot acts like a brush in removing the biofilm,” Professor Zhang Li from the university’s department of mechanical and automation engineering said.
The micromachine also contains hydrogel that can carry hydrogen peroxide, an antiseptic often used for wound care, to kill bacteria from the broken-up biofilm.
Researchers can decide when to release the antiseptic by heating up the micro robot through magnetic force.
The hydrogel will shrink when the temperature hits about 32 degrees Celsius (89 Fahrenheit) or more and release hydrogen peroxide.
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Zhang said that the chemical reaction between hydrogen peroxide and the magnetic effect of the micro robot could create free radicals, which could achieve a better bacteria-killing rate than the use of antiseptic alone.
Laboratory experiments with catheters showed that the device could remove 93 per cent of biofilm in just five minutes and achieve a bacteria kill rate of 99 per cent.
The research team said it would move on to clinical tests after another one to two years of refining the device and tests on animals.
The academics said they were also collaborating with non-medical sectors to apply the micro robots in industry and the environmental sectors, but Chan declined to reveal further details because of non-disclosure agreements.
But he added the technology could be adapted and deployed in oil pipelines or instruments that used water.
“We hope the micro robot could be used in tiny or precision instruments or tubes that are hard to take out for cleaning,” Chan said.
